N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

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Chemical Name:N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide
CAS No.:1415124-51-4
Molecular Formula:C₂₀H₁₈Cl₂N₄O₂
Molecular Weight:417.295
Hs Code.:

Synonyms:N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

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Chemical Property of N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

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Technology Process of N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

There total 4 articles about N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415125-23-3
N-{1-[4-(bromomethyl)-2,6-dichlorobenzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide

: 74-89-5
methylamine

: 1415124-51-4
N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

Guidance literature:: N-{1-[4-(bromomethyl)-2,6-dichlorobenzoyl]-1H-pyrrolo[3,2-c]pyridin-4-yl}cyclopropanecarboxamide; With caesium carbonate; In acetonitrile; for 0.25h;

methylamine; In acetonitrile; at 0 - 20 ℃; for 0.333333h;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1415124-51-4
N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuryl dichloride / diethyl ether / 15 h / 0 - 20 °C

2.1: sulfuric acid; sodium nitrite; acetic acid; phosphinic acid

3.1: sodium tetrahydroborate; methanol / tetrahydrofuran

4.1: pyridine; lithium iodide / 5 h / Reflux

5.1: dmap; N,N-dimethyl-aniline; 1-hydroxy-7-aza-benzotriazole; HATU

5.2: 15 h / 20 °C

6.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

7.1: caesium carbonate / acetonitrile / 0.25 h

7.2: 0.33 h / 20 °C

With pyridine; methanol; dmap; sodium tetrahydroborate; phosphinic acid; sulfuryl dichloride; 1-hydroxy-7-aza-benzotriazole; sulfuric acid; phosphorus tribromide; caesium carbonate; acetic acid; N,N-dimethyl-aniline; HATU; lithium iodide; sodium nitrite; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 264276-14-4
dimethyl 2,6-dichlorobenzene-1,4-dicarboxylate

: 1415124-51-4
N-(1-{2,6-dichloro-4-[(methylamino)methyl]benzoyl}-1H-pyrrolo[3,2-c]pyridin-4-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / tetrahydrofuran

2.1: pyridine; lithium iodide / 5 h / Reflux

3.1: dmap; N,N-dimethyl-aniline; 1-hydroxy-7-aza-benzotriazole; HATU

3.2: 15 h / 20 °C

4.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

5.1: caesium carbonate / acetonitrile / 0.25 h

5.2: 0.33 h / 20 °C

With pyridine; methanol; dmap; sodium tetrahydroborate; 1-hydroxy-7-aza-benzotriazole; phosphorus tribromide; caesium carbonate; N,N-dimethyl-aniline; HATU; lithium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;