2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Base Information

• Chemical Name: 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS No.: 495402-49-8
• Molecular Formula: C₁₉H₃₃BO₃Si
• Molecular Weight: 348.366

Synonyms:2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

There total 4 articles about 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(3‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenyl)methanol (443776-76-9) + tert-butyldimethylsilyl chloride (18162-48-6) → 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (495402-49-8)

Guidance literature:

With dmap; In tetrahydrofuran; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tet.2013.02.054

Reference yield: 55.0%

[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane (103978-12-7) + bis(pinacol)diborane (73183-34-3) → 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (495402-49-8)

Guidance literature:

With potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In dimethyl sulfoxide; at 100 ℃; for 16h;

DOI:10.1002/hlca.200590144

Reference yield:

(3-Bromophenyl)methanol (15852-73-0) → 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (495402-49-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / DMAP / tetrahydrofuran / 24 h / 25 °C

2: 55 percent / AcOK / [PdCl₂(dppf)2]*CH₂Cl₂ / dimethylsulfoxide / 16 h / 100 °C

With dmap; potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; dimethyl sulfoxide;

DOI:10.1002/hlca.200590144

upstream raw materials:

[(3-bromobenzyl)oxy](tert-butyl)dimethylsilane

bis(pinacol)diborane

(3-Bromophenyl)methanol

tert-butyldimethylsilyl chloride

Downstream raw materials:

(Zn(C₄NH₂C(C₆H₃(C(CH₃)3)2)C₄NH₂C(C₆H₄CH₂OSi(CH₃)2C(CH₃)3)C₄NH₂C(C₆H₃(C(CH₃)3)2)C₄NH₂C))2

[5,15-bis[3,5-di(tert-butyl)phenyl]-10-[3-(([(tert-butyl)(dimethyl)silyl]oxy)methyl)phenyl]porphyrinato(2-)-κN(21),κN(22),κN(23),κN(24)]zinc(II)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 495402-49-8 2-[3-({[(tert-butyl)(dimethyl)silyl]oxy}methyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Send

Send

Metric Ton KG G Pound L ML

Send

Send