[8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride

Base Information

Chemical Name:[8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride
CAS No.:1290053-81-4
Molecular Formula:C₂₃H₂₅BN₂O₃*ClH
Molecular Weight:424.735
Hs Code.:

Synonyms:[8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride

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Chemical Property of [8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride

Chemical Property:

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Technology Process of [8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride

There total 10 articles about [8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1290053-81-4
[8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 1 h / 90 °C

3.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

4.1: hydrogen / palladium-on-charcoal / methanol / 1 h

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 3 h / 0 - 20 °C

6.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium-on-charcoal; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1290056-73-3
tert-butyl 3-(1-(7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthoyl)piperidin-4-yl)benzylcarbamate

: 1290053-81-4
[8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 4h;

Reference yield:

: 286961-24-8
benzyl 1,2,3,6-tetrahydro-4-(trifluoromethylsulphonyloxy)-pyridine-1-carboxylate

: 1290053-81-4
[8-({4-[3-(aminomethyl)phenyl]piperidin-1-yl}carbonyl)naphthalen-2-yl]boronic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile; water / 1 h / 90 °C

2.1: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 0 - 20 °C / Cooling with ice

3.1: hydrogen / palladium-on-charcoal / methanol / 1 h

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.5 h / 0 °C

4.2: 3 h / 0 - 20 °C

5.1: hydrogenchloride / water; tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; dmap; sodium tetrahydroborate; hydrogen; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium-on-charcoal; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;