(4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

Base Information

Chemical Name:(4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester
CAS No.:79838-11-2
Molecular Formula:C₃₉H₃₇Cl₅N₅O₁₃P
Molecular Weight:991.987
Hs Code.:

(4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

Synonyms:(4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

Suppliers and Price of (4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

There total 3 articles about (4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 59819-52-2
2,2,2-trichloroethyl 2-chlorophenyl phosphorochloridate

: 60943-94-4
5'-O<(p-chlorophenoxy)acetyl>-2'-O-(4-methoxytetrahydro-4-pyranyl)-2-N-benzoylguanosine

: 79838-11-2
(4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: With 1-methyl-1H-imidazole; In acetonitrile;

Reference yield:

: 60943-92-2
2'-O-(4-methoxytetrahydropyran-4-yl)-N²-benzoylguanosine

: 79838-11-2
(4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / 2,6-lutidine / acetonitrile / 16 h / 0 °C

2: 63 percent / 1-methylimidazole / acetonitrile

With 1-methyl-1H-imidazole; 2,6-dimethylpyridine; In acetonitrile;

Reference yield:

: 4122-68-3
4-chlorophenyloxyacetyl chloride

: 79838-11-2
(4-Chloro-phenoxy)-acetic acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-3-[(2-chloro-phenoxy)-(2,2,2-trichloro-ethoxy)-phosphoryloxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / 2,6-lutidine / acetonitrile / 16 h / 0 °C

2: 63 percent / 1-methylimidazole / acetonitrile

With 1-methyl-1H-imidazole; 2,6-dimethylpyridine; In acetonitrile;