(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate

Base Information

Chemical Name:(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate
CAS No.:1088696-99-4
Molecular Formula:C₂₈H₃₃NO₄S₂
Molecular Weight:511.706
Hs Code.:

Synonyms:(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate

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Chemical Property of (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate

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Technology Process of (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate

There total 1 articles about (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 913288-73-0
(1S,2R)-2-(N-benzyl-N-mesitylenesulfonylamino)-1-phenylpropane-1-thiol

: 625-45-6
2-methoxyacetic acid

: 1088696-99-4
(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo801720v

Reference yield:

: 1088696-99-4
(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate

: 100-52-7
benzaldehyde

: 1088697-12-4
(1'S,2R,2'R,3S)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 3-hydroxy-2-methoxy-3-phenyl-thiopropionate

: 1088697-07-7
(1'S,2S,2'R,3R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 3-hydroxy-2-methoxy-3-phenyl-thiopropionate

Guidance literature:: (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate; With N-ethyl-N,N-diisopropylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

benzaldehyde; In dichloromethane; at -78 - 0 ℃; for 3.5h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo801720v

Reference yield:

: 1088696-99-4
(1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate

: 100-52-7
benzaldehyde

: S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 3-hydroxy-2-methoxy-3-phenyl-thiopropionate

: 1088697-12-4
(1'S,2R,2'R,3S)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 3-hydroxy-2-methoxy-3-phenyl-thiopropionate

: 1088697-07-7
(1'S,2S,2'R,3R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 3-hydroxy-2-methoxy-3-phenyl-thiopropionate

Guidance literature:: (1'S,2'R)-S-[2'-(N-benzyl-N-mesitylenesulfonylamino)-1'-phenylpropyl] 2-methoxy-thioacetate; With triethylamine; dicyclohexyl(((trifluoromethyl)sulfonyl)oxy)borane; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

benzaldehyde; In dichloromethane; at -78 - 0 ℃; for 3.5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/jo801720v