Technology Process of (2R,5R)-(-)-methyl 5-phenyl-1,4-dioxane-2-carboxylate
There total 6 articles about (2R,5R)-(-)-methyl 5-phenyl-1,4-dioxane-2-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere
1.2: Cooling with ice
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 20 °C
3.1: (1S)-10-camphorsulfonic acid / dichloromethane / 8 h / Reflux
4.1: potassium permanganate; potassium hydroxide / 18 h / 18 - 20 °C
5.1: sulfuric acid / 5 h / Reflux
With
potassium permanganate; lithium aluminium tetrahydride; sulfuric acid; (1S)-10-camphorsulfonic acid; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide;
In
diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2012.02.016
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: silver(l) oxide / diethyl ether / 2 h / Reflux
2.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere
2.2: Cooling with ice
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 20 °C
4.1: (1S)-10-camphorsulfonic acid / dichloromethane / 8 h / Reflux
5.1: potassium permanganate; potassium hydroxide / 18 h / 18 - 20 °C
6.1: sulfuric acid / 5 h / Reflux
With
potassium permanganate; lithium aluminium tetrahydride; sulfuric acid; (1S)-10-camphorsulfonic acid; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; silver(l) oxide;
In
diethyl ether; dichloromethane;
DOI:10.1016/j.bmc.2012.02.016
