N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine

Base Information

• Chemical Name: N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine
• CAS No.: 1266480-02-7
• Molecular Formula: C₁₆H₁₄IN₅
• Molecular Weight: 403.225
• Mol file: 1266480-02-7.mol

Synonyms:N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine

Chemical Property of N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine

There total 4 articles about N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

5-cyclopropyl-2H-pyrazol-3-ylamine (175137-46-9) + 4-bromo-5-iodo-2-phenylpyrimidine (1266480-01-6) → N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine (1266480-02-7)

Guidance literature:

In butan-1-ol; at 90 ℃; for 24h;

Reference yield:

2-phenyl-4-hydroxypyrimidine (33643-94-6,127892-81-3) → N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine (1266480-02-7)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; N-iodo-succinimide / 1 h / 50 °C

2: phosphorus(V) oxybromide / 8 h / 100 °C

3: butan-1-ol / 24 h / 90 °C

With N-iodo-succinimide; acetic acid; phosphorus(V) oxybromide; In butan-1-ol;

Reference yield:

benzamidene hydrochloride (15934-46-0) → N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-iodo-2-phenylpyrimidin-4-amine (1266480-02-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / ethanol / 15 h / Reflux; Inert atmosphere

2: acetic acid; N-iodo-succinimide / 1 h / 50 °C

3: phosphorus(V) oxybromide / 8 h / 100 °C

4: butan-1-ol / 24 h / 90 °C

With N-iodo-succinimide; potassium carbonate; acetic acid; phosphorus(V) oxybromide; In ethanol; butan-1-ol;

upstream raw materials:

benzamidene hydrochloride

2-phenyl-4-hydroxypyrimidine

5-cyclopropyl-2H-pyrazol-3-ylamine

4-bromo-5-iodo-2-phenylpyrimidine

Downstream raw materials:

tert-butyl 5-cyclopropyl-3-(5-iodo-2-phenylpyrimidin-4-ylamino)-1H-pyrazole-1-carboxylate

N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-ethynyl-2-phenyl-pyrimidin-4-amine

N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-phenyl-5-((trimethylsilyl)ethynyl)pyrimidin-4-amine

(E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-(3-methoxyprop-1-enyl)-2-phenyl-pyrimidin-4-amine