tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Base Information

Chemical Name:tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate
CAS No.:1312691-89-6
Molecular Formula:C₃₁H₄₁N₇O₅
Molecular Weight:591.71
Hs Code.:

tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Synonyms:tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

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Chemical Property of tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

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Technology Process of tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

There total 5 articles about tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1312691-88-5
ethyl 2-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-6-methylpyrimidine-5-carboxylate

: 1312691-89-6
tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Guidance literature:: ethyl 2-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-6-methylpyrimidine-5-carboxylate; With selenium(IV) oxide; In 1,4-dioxane; at 100 ℃; for 24h;

2,4-Dimethoxybenzylamine; With sodium acetate; In methanol; dichloromethane; at 20 ℃; for 0.5h;

With methanol; sodium cyanoborohydride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 583878-42-6
ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate

: 1312691-89-6
tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ISOPROPYLAMIDE / 5 h / 80 °C / 760.05 Torr / Inert atmosphere; Sealed tube

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.25 h / 20 °C / Cooling with ice

3.1: triethylamine / ISOPROPYLAMIDE / 8 h / 90 °C / Sealed tube

4.1: selenium(IV) oxide / 1,4-dioxane / 24 h / 100 °C

4.2: 0.5 h / 20 °C

4.3: 2 h / 20 °C

With selenium(IV) oxide; sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; 1.1: Suzuki Coupling;

Reference yield:

: 344361-90-6
4-hydroxy-6-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester

: 1312691-89-6
tert-Butyl (1S,2R)-2-(6-(2,4-dimethoxybenzyl)-4-(1,5-dimethyl-1H-pyrazol-4-yl)-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-ylamino)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetraethylammonium chloride; trichlorophosphate; N,N-dimethyl-aniline / acetonitrile / 4 h / 100 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ISOPROPYLAMIDE / 5 h / 80 °C / 760.05 Torr / Inert atmosphere; Sealed tube

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.25 h / 20 °C / Cooling with ice

4.1: triethylamine / ISOPROPYLAMIDE / 8 h / 90 °C / Sealed tube

5.1: selenium(IV) oxide / 1,4-dioxane / 24 h / 100 °C

5.2: 0.5 h / 20 °C

5.3: 2 h / 20 °C

With selenium(IV) oxide; tetraethylammonium chloride; sodium carbonate; N,N-dimethyl-aniline; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane; ISOPROPYLAMIDE; acetonitrile; 2.1: Suzuki Coupling;