2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

Base Information

Chemical Name:2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine
CAS No.:1217551-13-7
Molecular Formula:C₁₇H₁₂Cl₂F₄N₂O
Molecular Weight:407.195
Hs Code.:

Synonyms:2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

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Chemical Property of 2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

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Technology Process of 2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

There total 5 articles about 2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1217551-12-6
3-(3-azidomethyl-4-fluorophenyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole

: 1217551-13-7
2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

Guidance literature:: 3-(3-azidomethyl-4-fluorophenyl)-5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole; With tin(II) chloride dihdyrate; In methanol; at 20 ℃; Cooling with ice;

With sodium hydroxide; In water;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1217551-13-7
2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 70 °C

1.2: 0 - 20 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C

4.1: tin(II) chloride dihdyrate / methanol / 20 °C / Cooling with ice

With N-chloro-succinimide; N-Bromosuccinimide; sodium azide; tin(II) chloride dihdyrate; dibenzoyl peroxide; In methanol; tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 5-(3,5-dichlorophenyl)-3-(4-fluoro-3-methyl-phenyl)-5-(trifluoromethyl)-4H-isoxazole

: 1217551-13-7
2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux

2: sodium azide / N,N-dimethyl-formamide / 20 °C

3: tin(II) chloride dihdyrate / methanol / 20 °C / Cooling with ice

With N-Bromosuccinimide; sodium azide; tin(II) chloride dihdyrate; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide;