N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide

Base Information

Chemical Name:N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide
CAS No.:1217550-52-1
Molecular Formula:C₂₀H₁₆Cl₂F₄N₂O₂
Molecular Weight:463.259
Hs Code.:

Synonyms:N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide

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Chemical Property of N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide

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Technology Process of N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide

There total 5 articles about N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1217551-13-7
2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl amine

: 802294-64-0,79-09-4
propionic acid

: 1217550-52-1
N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; Cooling with ice;

Reference yield:

: 864725-22-4
1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene

: 1217550-52-1
N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 70 °C

1.2: 0 - 20 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C

4.1: tin(II) chloride dihdyrate / methanol / 20 °C / Cooling with ice

5.1: pyridine / dichloromethane / 20 °C / Cooling with ice

With pyridine; N-chloro-succinimide; N-Bromosuccinimide; sodium azide; tin(II) chloride dihdyrate; dibenzoyl peroxide; In methanol; tetrachloromethane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 928064-04-4
[C(E)]-4-fluoro-3-methylbenzaldehyde oxime

: 1217550-52-1
N-{2-fluoro-5-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-benzyl}-propionic acid amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / 1,2-dimethoxyethane / 2 h / 70 °C

1.2: 0 - 20 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C

4.1: tin(II) chloride dihdyrate / methanol / 20 °C / Cooling with ice

5.1: pyridine / dichloromethane / 20 °C / Cooling with ice

With pyridine; N-chloro-succinimide; N-Bromosuccinimide; sodium azide; tin(II) chloride dihdyrate; dibenzoyl peroxide; In methanol; tetrachloromethane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;