indan-2-ylphenylpyrrolidin-2-ylmethylamine

Base Information

Chemical Name:indan-2-ylphenylpyrrolidin-2-ylmethylamine
CAS No.:1393836-88-8
Molecular Formula:C₂₀H₂₄N₂
Molecular Weight:292.424
Hs Code.:

Synonyms:indan-2-ylphenylpyrrolidin-2-ylmethylamine

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Chemical Property of indan-2-ylphenylpyrrolidin-2-ylmethylamine

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Technology Process of indan-2-ylphenylpyrrolidin-2-ylmethylamine

There total 8 articles about indan-2-ylphenylpyrrolidin-2-ylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

: 1393836-87-7
(1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

: 1393836-88-8
indan-2-ylphenylpyrrolidin-2-ylmethylamine

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; for 6h; Inert atmosphere; Reflux;

Reference yield:

: 15761-39-4,59433-50-0
N-tert-butoxycarbonyl-proline

: 1393836-88-8
indan-2-ylphenylpyrrolidin-2-ylmethylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 24 h / 0 - 20 °C

2.1: dichloromethane / 4 h / 20 °C / Cooling with ice

3.1: potassium carbonate / acetonitrile / 0.25 h / 0 °C

3.2: 16 h / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

6.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C

7.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; microwave

8.1: ammonium formate / palladium 10% on activated carbon / methanol / 6 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; ammonium formate; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; DavePhos; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 67131-44-6
1-benzyl-2-(hydroxymethyl)pyrrolidine

: 1393836-88-8
indan-2-ylphenylpyrrolidin-2-ylmethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C

3: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; microwave

4: ammonium formate / palladium 10% on activated carbon / methanol / 6 h / Inert atmosphere; Reflux

With oxalyl dichloride; potassium tert-butylate; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; DavePhos; In 1,4-dioxane; methanol; dichloromethane;