(1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

Base Information

Chemical Name:(1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine
CAS No.:1393836-87-7
Molecular Formula:C₂₇H₃₀N₂
Molecular Weight:382.549
Hs Code.:

Synonyms:(1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

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Chemical Property of (1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

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Technology Process of (1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

There total 6 articles about (1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67131-44-6
1-benzyl-2-(hydroxymethyl)pyrrolidine

: 1393836-87-7
(1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

2: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C

3: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; microwave

With oxalyl dichloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; acetic acid; dimethyl sulfoxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In 1,4-dioxane; dichloromethane;

Reference yield:

: trifluoroacetate of 5-methylproline methyl ester

: 1393836-87-7
(1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetonitrile / 0.25 h / 0 °C

1.2: 16 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C

5.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; microwave

With lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 145681-01-2
(+/-)-N-tert-butoxycarbonylproline methyl ester

: 1393836-87-7
(1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 4 h / 20 °C / Cooling with ice

2.1: potassium carbonate / acetonitrile / 0.25 h / 0 °C

2.2: 16 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Cooling with ice

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 0 - 20 °C

6.1: potassium tert-butylate / DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; microwave

With lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; dimethyl sulfoxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; DavePhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;