67131-44-6

Usage

Uses

Used in Pharmaceutical Industry:
(1-BENZYLPYRROLIDIN-2-YL)METHANOL is used as a building block for the synthesis of various drugs and bioactive compounds, contributing to the development of new medications for the treatment of different medical conditions.
Used in Medicinal Chemistry:
(1-BENZYLPYRROLIDIN-2-YL)METHANOL is utilized in the research and development of new pharmaceuticals, playing a crucial role in the advancement of treatment options for various diseases and disorders.
Used in Organic Synthesis:
(1-BENZYLPYRROLIDIN-2-YL)METHANOL is employed as a chiral auxiliary in asymmetric synthesis, facilitating the production of enantiomerically pure compounds, which are essential in the creation of biologically active molecules.
Used in Asymmetric Catalysis:
(1-BENZYLPYRROLIDIN-2-YL)METHANOL is used as a chiral ligand in asymmetric catalysis, enhancing the selectivity and efficiency of chemical reactions, leading to the production of desired enantiomers in a more controlled manner.

InChI:InChI=1/C12H17NO/c14-10-12-7-4-8-13(12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2

Upstream product

• 195719-48-3 N-benzoylproline 
• 98-88-4 benzoyl chloride 
• 60169-72-4 1-benzyl-pyrrolidine-2-carboxylic acid 
• 15761-39-4 N-tert-butoxycarbonyl-proline 
• 145681-01-2 (+/-)-N-tert-butoxycarbonylproline methyl ester 
• 1104194-23-1 benzyl 1-benzylpyrrolidine-2-carboxylate 
• 330173-08-5 N-benzyl-2-(4-methylphenylsulfonyl)acetamide 
• 116041-30-6 5-hydroxymethyl-1-phenylmethyl-2-pyrrolidinone 
• 498-63-5 2-hydroxymethylpyrrolidine 
• 609-36-9 rac-Pro-OH 

Downstream Products

• 130054-62-5 3-Oxo-butyric acid 1-benzyl-pyrrolidin-2-ylmethyl ester 
• 1252879-81-4 1-benzyl-2-(bromomethyl)pyrrolidine 
• 1353986-84-1 1-benzylpyrrolidine-2-carboxaldehyde 
• 1393836-86-6 (1-benzylpyrrolidin-2-ylmethyl)indan-2-yl-amine 
• 1393836-87-7 (1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine 
• 1393836-88-8 indan-2-ylphenylpyrrolidin-2-ylmethylamine 
• 1608125-69-4 5-((1-benzylpyrrolidin-2-yl)methoxy)-3-methyl-1-phenyl-1H-pyrazole 
• 60169-71-3 1-benzyl-2-(chloromethyl)pyrrolidinium chloride 
• 130054-66-9 2-[1-(3-Nitro-phenyl)-meth-(E)-ylidene]-3-oxo-butyric acid 1-benzyl-pyrrolidin-2-ylmethyl ester 

Relevant academic research and scientific papers

USE OF AMINOINDANE COMPOUNDS IN TREATING OVERACTIVE BLADDER AND INTERSTITIAL CYSTITIS

The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the compounds to a patient.

Asymmetric synthesis of (-)-(1R,7aS)-absouline

The most efficient and concise asymmetric synthesis of (-)-(1R,7aS)- absouline to date, which was accomplished in eight steps and 20% overall yield from commercially available starting materials, is described. The doubly diastereoselective conjugate addit

Aminoindane Compounds and Use Thereof in Treating Pain

The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV 1 receptor activator. In one embodiment, the TRPV 1 receptor activator is lidocaine.

Palladium(II)-N-heterocyclic carbene complexes derived from proline: Synthesis and characterization

Pd(II)-N-heterocyclic carbene complexes derived from proline have been successfully synthesized in good yields and their structures have been characterized by X-ray single crystal diffraction. It was found that the substituents on the N-atom of the pyrrolidine skeleton dramatically affect on the coordination pattern of the palladium complexes. In a word, when an electron-rich group as benzyl group was attached on the N-atom, both of the N-atom and NHC were coordinated to the Pd(II) center; while when an electron-poor group as Ts group was attached, a dimeric mono-coordinated Pd(II)-NHC was obtained exclusively.

MACROCYCLIC INDOLE DERIVATIVES FOR THE TREATMENT OF HEPATITIS C INFECTIONS

A class of macrocyclic compounds of formula (I), wherein R7, R9, B, F, M, Q, W, Y and Z are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also p

New synthesis and application of 3-substituted prolinols

Carbon skeleton of polysubstituted pyroglutamates with three contiguous asymmetric centers was built up in one base-induced coupling/cyclization reaction of α-sulfonylacetamide with 2-bromo-2-propenoates. A simple transformation to 3-substituted prolinols

Reaction of 1-(R-sulfonyl)indoles with N,N-dibenzyl-β-amino alcohols

The reaction of 1-(methylsulfonyl)- and 1-(phenylsulfonyl)indoles with N,N-dibenzylamino alcohols leads to the formation of a mixture of isomeric 1-(β-aminoethyl)indoles.

Novel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-positions

Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N,N-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxyl ate, I-43 (CS-905), exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.