3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde

Base Information

• Chemical Name: 3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde
• CAS No.: 928837-32-5
• Molecular Formula: C₁₇H₂₅N₃O₇
• Molecular Weight: 383.401
• Mol file: 928837-32-5.mol

Synonyms:3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde

Chemical Property of 3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde

There total 1 articles about 3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-hydroxy-4,5-dimethoxybenzaldehyde (29865-90-5) + 11-azide-1-{(methylsulfonyl)oxy}-3,6,9-trioxaundecane (134179-43-4) → 3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde (928837-32-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 17h; Product distribution / selectivity;

Reference yield: 80.0%

3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde (928837-32-5) + ethylene glycol (107-21-1) → 2-(3-{2-[2-(2-{2-azidoethoxy}ethoxy)ethoxy]ethoxy}-4,5-dimethoxyphenyl)-1,3-dioxolane (928837-35-8)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 8h; Heating / reflux;

Reference yield: 72.0%

3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde (928837-32-5) + 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester (162256-49-7) → 3-benzo[1,3]dioxol-5-yl-4-(3-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)-4,5-dimethoxybenzyl)-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one (928837-33-6)

Guidance literature:

3-(2-{2-[2-(2-azidoethoxy)ethox]ethoxy}ethoxy)-4,5-dimethoxybenzaldehyde; 2-benzo<1,3>dioxol-5-yl-4-(4-methoxyphenyl)-4-oxobutyric acid methyl ester; With sodium methylate; In methanol; at 0 ℃; for 15h; Heating / reflux;

With acetic acid; In methanol; for 5h; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

3-hydroxy-4,5-dimethoxybenzaldehyde

11-azide-1-{(methylsulfonyl)oxy}-3,6,9-trioxaundecane

Downstream raw materials:

2-(3-{2-[2-(2-{2-azidoethoxy}ethoxy)ethoxy]ethoxy}-4,5-dimethoxyphenyl)-1,3-dioxolane

3-benzo[1,3]dioxol-5-yl-4-(3-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)-4,5-dimethoxybenzyl)-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one

3-benzo[1,3]-dioxol-5-yl-4-[3-(2-{2-[2-(2-{4-[4-(2-fluoropyridin-3-yloxy)butyl]-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethoxy}ethoxy)-4,5-dimethoxybenzyl]-5-hydroxy-5-(4-methoxyphenyl)-5H-furan-2-one

N-[-1-(2-{2-[2-(2-{5-[4-benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-ylmethyl]-2,3-dimethoxyphenoxy}ethoxy)ethoxy]ethoxy}ethyl)-1H-1,2,3-triazol-4-ylmethyl]-4-fluoro-N-methylbenzenesulfonamide