2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester

Base Information

• Chemical Name: 2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester
• CAS No.: 252750-39-3
• Molecular Formula: C₁₆H₂₂N₄O₃
• Molecular Weight: 318.376

Synonyms:2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester

Chemical Property of 2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester

Chemical Property:

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Technology Process of 2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester

There total 1 articles about 2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tert-butylketene methyl trimethylsilyl acetal (92984-36-6) + 5-amino-1-phenyl-1H-1,2,3-triazole-4-carboxaldehyde (73112-03-5) + Phenyl azide (622-37-7) + methyl 2-cyanoacetate (105-34-0) → 2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester (252750-39-3)

Guidance literature:

With trifluoroborane diethyl ether; In dichloromethane;

Reference yield: 70.0%

5-amino-1-(2-fluorophenyl)-4-formyl-1H-1,2,3-triazole (252750-53-1) + 2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester (252750-39-3) + 1-azido-2-fluorobenzene (3296-04-6) + methyl 2-cyanoacetate (105-34-0) → 2-[α-(5-Amino-1-(2-fluorophenyl)-1H-1,2,3,triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester + 2-[α-(5-amino-1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester (252750-42-8)

Guidance literature:

Reference yield: 68.0%

2-[α-(5-amino-1-phenyl-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester (252750-39-3) + 2-azido-1,3-difluorobenzene (102284-85-5) + ethyl 2-cyanoacetate (105-56-6) → 2-[α-(5-amino-1-(2,6-difluorophenyl)-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester (252750-46-2)

Guidance literature:

upstream raw materials:

tert-butylketene methyl trimethylsilyl acetal

5-amino-1-phenyl-1H-1,2,3-triazole-4-carboxaldehyde

Phenyl azide

methyl 2-cyanoacetate

Downstream raw materials:

2-[α-(5-amino-1-(2,6-difluorophenyl)-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester

2-[α-(5-amino-1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl)-α-hydroxymethyl]-3,3-dimethylbutyric acid methyl ester

3-phenyl-6-(tert-butyl)-3,4-dihydro-1,2,3-triazolo[4,5-b]pyridin-5-one

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