N-(4-fluorophenyl)pyrrolidine-1-carbothioamide

Base Information

• Chemical Name: N-(4-fluorophenyl)pyrrolidine-1-carbothioamide
• CAS No.: 6232-83-3
• Molecular Formula: C₃H₅N₃S
• Molecular Weight: 115.159
• Mol file: 6232-83-3.mol

Synonyms:

Chemical Property of N-(4-fluorophenyl)pyrrolidine-1-carbothioamide

Chemical Property:

• Vapor Pressure: 0.000726mmHg at 25°C
• Boiling Point: 307.4°Cat760mmHg
• Flash Point: 139.7°C
• Density: 1.315g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-fluorophenyl)pyrrolidine-1-carbothioamide

There total 6 articles about N-(4-fluorophenyl)pyrrolidine-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

1-formyl-4-methyl-3-thiosemicarbazide (58064-52-1) → 4-methyl-1,2,4-triazoline-5-thione (24854-43-1,6232-83-3)

Guidance literature:

With sodium carbonate; In water; for 1h; Heating;

Reference yield:

2-bromo-1,3,4-thiadiazole (61929-24-6) + methylamine (74-89-5) → 4-methyl-1,2,4-triazoline-5-thione (24854-43-1,6232-83-3)

Guidance literature:

With ethanol; at 150 ℃;

Reference yield:

2-(Methylamino)-1,3,4-thiadiazol (38490-45-8) + methylamine (74-89-5) → 4-methyl-1,2,4-triazoline-5-thione (24854-43-1,6232-83-3)

Guidance literature:

With methanol; at 150 - 160 ℃;

upstream raw materials:

2-bromo-1,3,4-thiadiazole

methylamine

2-(Methylamino)-1,3,4-thiadiazol

methanol

Refernces

• 1、 Khatale, Pravin N.,Shivkumar,Manikrao, Anil M.,Mahajan, Niranjan S.,Jawarkar, Rahul D.. "Synthesis and biological screening of 3-(N-substituted carboxamidomethylthio)-4-methyl-(4H)-1,2,4-triazoles". . p. 349 - 354. Retrieved 2013/09/24.