dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester

Base Information

• Chemical Name: dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester
• CAS No.: 288852-84-6
• Molecular Formula: C₁₉H₂₉N₃O₆S
• Molecular Weight: 427.522
• Mol file: 288852-84-6.mol

Synonyms:dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester

Chemical Property of dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester

There total 3 articles about dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-Dimethylthiocarbamoyl chloride (16420-13-6) + 3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-hydroxy-5-nitro-benzaldehyde (288852-83-5) → dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester (288852-84-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1039/a903877i

Reference yield:

N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine (288852-82-4) → dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester (288852-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / p-toluenesulfonic acid; hydrogen / Pd/C / ethanol / 6 h / 120 °C / 5700.38 Torr

2: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

3: triethylamine / dimethylformamide / 15 h / 0 - 20 °C

With hydrogen; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; 1: Hydrogenolysis / 2: Alkylation / 3: Substitution;

DOI:10.1021/jo000175r

Reference yield:

bis-(2-ethoxyethyl)amine (124-21-0) → dimethyl-thiocarbamic acid O-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester (288852-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

2: triethylamine / dimethylformamide / 15 h / 0 - 20 °C

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Alkylation / 2: Substitution;

DOI:10.1021/jo000175r

upstream raw materials:

N,N-Dimethylthiocarbamoyl chloride

3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-hydroxy-5-nitro-benzaldehyde

bis-(2-ethoxyethyl)amine

N-benzyl-2-ethoxy-N-(2-ethoxyethyl)ethanamine

Downstream raw materials:

3-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-2-mercapto-5-nitro-benzaldehyde

dimethyl-thiocarbamic acid S-(2-{[bis-(2-ethoxy-ethyl)-amino]-methyl}-6-formyl-4-nitro-phenyl) ester