N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Base Information

Chemical Name:N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide
CAS No.:106665-50-3
Molecular Formula:C₁₈H₁₉N₅O₃
Molecular Weight:353.381
Hs Code.:

Synonyms:N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Suppliers and Price of N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

There total 7 articles about N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57345-51-4
(1S,2R,4R)-4-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentan-1-ol

: 98-88-4
benzoyl chloride

: 106665-50-3
N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Guidance literature:: (1S,2R,4R)-4-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)cyclopentan-1-ol; With pyridine; chloro-trimethyl-silane; at 0 - 20 ℃; for 1.25h;

benzoyl chloride; at 0 - 20 ℃; for 13h;

Reference yield:

: 98-88-4
benzoyl chloride

: 123577-78-6
2'-Deoxy-3',5'-O-TPDS-aristeromycin

: 106665-50-3
N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Guidance literature:: benzoyl chloride; 2'-Deoxy-3',5'-O-TPDS-aristeromycin; With pyridine;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 24 ℃;
DOI:10.1021/tx9701539

Reference yield:

: 19186-33-5
aristeromycin

: 106665-50-3
N-(9-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-9H-purin-6-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 76 percent / pyridine / 12 h

2.1: 90 percent / N,N-(dimethylamino)pyridine / acetonitrile / 10 h / 55 °C

3.1: 91 percent / Tributyltin hydride; AIBN / toluene / 3 h / 75 °C

4.1: pyridine

4.2: tetrabutylammonium fluoride / tetrahydrofuran / 24 °C

With pyridine; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; acetonitrile; 1.1: silylation / 2.1: phenylthiocarbonylation / 3.1: Reduction / 4.1: Benzoylation / 4.2: Desilylation;
DOI:10.1021/tx9701539