cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

Base Information

Chemical Name:cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate
CAS No.:89848-11-3
Molecular Formula:C₃₆H₃₄Cl₂N₆O₅
Molecular Weight:701.609
Hs Code.:

Synonyms:cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

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Chemical Property of cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

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Technology Process of cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

There total 7 articles about cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 89848-09-9
cis-1-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>benzenamine

: 1885-14-9
phenyl chloroformate

: 89848-11-3
cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

Guidance literature:: With pyridine; In chloroform; for 3h;
DOI:10.1021/jm00373a015

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 89848-11-3
cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 50 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

2: 80 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

3: 86 percent / pyridine / CHCl₃ / 3 h

With thiophene; pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00373a015

Reference yield:

: 67914-86-7,854372-78-4
cis-[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate

: 89848-11-3
cis-phenyl 1-<4-<4-<4-<<2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl>methoxy>phenyl>-1-piperazinyl>phenyl>carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) Me₂SO, 1 h, 2.) Me₂SO, 80 deg C, 5 h

2: 70 percent / NaOH / butan-1-ol / Heating

3: 50 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

4: 80 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

5: 86 percent / pyridine / CHCl₃ / 3 h

With thiophene; pyridine; sodium hydroxide; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015