1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester
• CAS No.: 1226786-03-3
• Molecular Formula: C₁₄H₁₆ClNO₃
• Molecular Weight: 281.739
• Mol file: 1226786-03-3.mol

Synonyms:1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

Chemical Property of 1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester

There total 3 articles about 1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

→ 1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester (1226786-03-3)

Guidance literature:

Reference yield:

pyrrolidine-3-carboxylic acid (59378-87-9,68464-02-8,72580-53-1,72580-54-2) → 1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester (1226786-03-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 10 h / 0 - 40 °C

2: triethylamine / dichloromethane / 4 h / Reflux

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.3390/molecules22101766

Reference yield:

3-ethoxycarbonyl-pyrrolidine (72925-15-6,81049-27-6,81049-29-8) + 4-chloro-benzoyl chloride (122-01-0) → 1-(4-chloro-benzoyl)-pyrrolidine-3-carboxylic acid ethyl ester (1226786-03-3)

Guidance literature:

With triethylamine; In dichloromethane; for 4h; Reflux;

DOI:10.3390/molecules22101766

upstream raw materials:

pyrrolidine-3-carboxylic acid

3-ethoxycarbonyl-pyrrolidine

4-chloro-benzoyl chloride