ethyl pyrrolidine-3-carboxylate

Base Information

• Chemical Name: ethyl pyrrolidine-3-carboxylate
• CAS No.: 72925-15-6
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.186
• Hs Code.: 2933990090
• Mol file: 72925-15-6.mol

Synonyms:Ethyl pyrrolidine-3-carboxylate;

Chemical Property of ethyl pyrrolidine-3-carboxylate

Chemical Property:

• Refractive Index: 1.4531
• Boiling Point: 191.3 °C at 760 mmHg
• PKA: 9.49±0.10(Predicted)
• Flash Point: 69.5 °C
• PSA: 38.33000
• Density: 1.031 g/cm³
• LogP: 0.48780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99.3% ^*data from raw suppliers

Ethylpyrrolidine-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 3-pyrrolidinecarboxylate is used to prepare inhibitors of γ-aminobutyric acid transporter 1.

Technology Process of ethyl pyrrolidine-3-carboxylate

There total 7 articles about ethyl pyrrolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-benzyl-3-carboethoxypyrrolidine (5747-92-2) → 3-ethoxycarbonyl-pyrrolidine (72925-15-6,81049-27-6,81049-29-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; for 6h; under 3102.97 Torr;

Reference yield:

pyrrolidine-3-carboxylic acid (59378-87-9,68464-02-8,72580-53-1,72580-54-2) + ethanol (64-17-5) → 3-ethoxycarbonyl-pyrrolidine (72925-15-6,81049-27-6,81049-29-8)

Guidance literature:

With thionyl chloride; In ethanol; at 0 - 80 ℃;

Reference yield:

N-benzylpyrrolidine (29897-82-3) → 3-ethoxycarbonyl-pyrrolidine (72925-15-6,81049-27-6,81049-29-8)

Guidance literature:

Pd(OH)2; In methanol-dichloromethane; ethanol;

upstream raw materials:

1-benzyl-3-carboethoxypyrrolidine

ethyl acrylate

N-benzylpyrrolidine

pyrrolidine-3-carboxylic acid

Downstream raw materials:

1-benzyl-3-carboethoxypyrrolidine

Refernces

• 1、 -. "SUBSTITUTED HETEROCYCLIC COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TRKA) INHIBITORS". Paragraph 0670 - 0672. . Retrieved 2015/02/05.
• 2、 -. "QUINOLONE ANTIBACTERIAL AGENTS". Page/Page column 89; 90; 129; 130. . Retrieved 2010/02/12.