4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole

Base Information

Chemical Name:4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole
CAS No.:1960-93-6
Molecular Formula:C₁₂H₁₀FNO₃
Molecular Weight:235.215
Hs Code.:
DSSTox Substance ID:DTXSID601153577

Synonyms:1960-93-6;Methyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate;SCHEMBL5773636;4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole;methyl-3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylate;WBIUQMSYYDVRJG-UHFFFAOYSA-N;DTXSID601153577;MFCD19354085;SY331878;DB-086276;4-Isoxazolecarboxylic acid, 3-(2-fluorophenyl)-5-methyl-, methyl ester

Suppliers and Price of 4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:235.06447134
Heavy Atom Count:17
Complexity:287

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C(=NO1)C2=CC=CC=C2F)C(=O)OC

Technology Process of 4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole

There total 2 articles about 4-Methoxycarbonyl-5-methyl-3-(2-fluorophenyl)isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 39502-43-7
2-fluoro-N-hydroxybenzenecarboxymidoyl chloride

: 23326-27-4
Methyl 2-butynoate

: 1960-93-6
methyl-3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylate

Guidance literature:: With triethylamine; In diethyl ether; at 20 ℃; for 18h;

Reference yield:

: 39502-43-7
2-fluoro-N-hydroxybenzenecarboxymidoyl chloride

: 105-45-3
acetoacetic acid methyl ester

: 1960-93-6
methyl-3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylate

Guidance literature:: Multistep reaction; (i) Na, MeOH, (ii) /BRN= 506727/;
DOI:10.1039/jr9630005838

Reference yield: 96.0%

: 1960-93-6
methyl-3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylate

: 1736-20-5
3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylic acid

Guidance literature:: methyl-3-(2-fluorophenyl)-5-methylisoxazol-4-carboxylate; With sodium hydroxide; In methanol; water; at 50 ℃; for 19h;

With hydrogenchloride; In methanol; water; pH=< 3;