2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide

Base Information

• Chemical Name: 2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide
• CAS No.: 1277181-62-0
• Molecular Formula: C₁₈H₂₀N₆O₂S₂
• Molecular Weight: 416.528
• Mol file: 1277181-62-0.mol

Synonyms:2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide

Chemical Property of 2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide

There total 2 articles about 2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenyl-1-ethanone (17385-78-3) + semicarbazide hydrochloride (563-41-7) → 2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide (1277181-62-0)

Guidance literature:

With tetrabutylammomium bromide; sodium acetate; In 1,4-dioxane; water; at 20 ℃; for 72h;

DOI:10.1080/17415993.2010.533772

Reference yield:

α-bromoacetophenone (70-11-1) → 2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide (1277181-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / ethanol; N,N-dimethyl-formamide / 2 h

2: tetrabutylammomium bromide; sodium acetate / 1,4-dioxane; water / 72 h / 20 °C

With tetrabutylammomium bromide; sodium acetate; triethylamine; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1080/17415993.2010.533772

Reference yield: 42.0%

2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide (1277181-62-0) → 4-phenyl-1,2,3-thiadiazole (25445-77-6)

Guidance literature:

With thionyl chloride; at -5 ℃;

DOI:10.1080/17415993.2010.533772

upstream raw materials:

2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenyl-1-ethanone

semicarbazide hydrochloride

α-bromoacetophenone

Downstream raw materials:

4-phenyl-1,2,3-thiadiazole