2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenylethanone

Base Information

• Chemical Name: 2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenylethanone
• CAS No.: 17385-78-3
• Molecular Formula: C11H11NOS2
• Molecular Weight: 237.346
• DSSTox Substance ID: DTXSID70355236
• Wikidata: Q82133999
• Mol file: 17385-78-3.mol

Synonyms:17385-78-3;ST51039374;SCHEMBL5369978;DTXSID70355236;AKOS002720384;2-(4,5-dihydrothiazol-2-ylthio)-1-phenylethanone

Chemical Property of 2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenylethanone

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 237.02820632
• Heavy Atom Count: 15
• Complexity: 259

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSC(=N1)SCC(=O)C2=CC=CC=C2

Technology Process of 2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenylethanone

There total 3 articles about 2-(4,5-Dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenylethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-mercaptothiazoline (96-53-7) + α-bromoacetophenone (70-11-1) → 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenyl-1-ethanone (17385-78-3)

Guidance literature:

2-mercaptothiazoline; With sodium carbonate; In ethanol; water; at 20 ℃;

α-bromoacetophenone; In ethanol; water; at 20 ℃;

DOI:10.1016/j.jfluchem.2009.12.022

Reference yield: 85.0%

thallium salt of Δ2-1,3-thiazoline-2-thiol (63987-96-2) + α-bromoacetophenone (70-11-1) → 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenyl-1-ethanone (17385-78-3)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1039/P19810000914

Reference yield:

→ 2-(4,5-dihydro-1,3-thiazol-2-ylsulfanyl)-1-phenyl-1-ethanone (17385-78-3)

Guidance literature:

Entspr. Halogenacetylverb., /BRN= 99077/ in THF/HMPT;

DOI:10.1016/S0040-4039(01)93013-8

upstream raw materials:

2-mercaptothiazoline

α-bromoacetophenone

thallium salt of Δ²-1,3-thiazoline-2-thiol

Downstream raw materials:

2-[(Z)-2-(2-[(Z)-2-(aminocarbonyl)hydrazono]-2-phenylethyldisulfanyl)-1-phenylethylidene]-1-hydrazinecarboxamide

2-[2-(hydroxyimino)-2-phenylethyl]disulfanyl-1-phenyl-1-ethanone oxime

2,7-dihydro-3,6-diphenyl-1,4,5-thiadiazepine

2-(4,5-dihydrothiazol-2-ylsulfonyl)-1-phenylethanone