(R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate
CAS No.:1240914-48-0
Molecular Formula:C₂₁H₂₉N₃O₄
Molecular Weight:387.479
Hs Code.:

Synonyms:(R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

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Chemical Property of (R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

There total 9 articles about (R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 75336-86-6
(2R)-methylpiperazine

: 1240914-48-0
(R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: trans-2-(4-carbamoylphenyl)cyclopropanecarboxylic acid

: 163765-44-4
(R)-tert-butyl 3-methylpiperazine-1-carboxylate

: 1240914-48-0
(R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield:

: trans-[2-(4-bromo-phenyl)-cyclopropyl]-methanol

: 1240914-48-0
(R)-tert-butyl 4-(trans-2-(4-carbamoylphenyl)cyclopropanecarbonyl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate / ISOPROPYLAMIDE / 17 h / 150 °C / Inert atmosphere

2.1: Jones reagent / acetone / -10 - 20 °C

3.1: potassium hydroxide / tert-butyl alcohol / 70 °C

3.2: pH 4 - 5

4.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C

With Jones reagent; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; In ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;