N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide

Base Information

Chemical Name:N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide
CAS No.:1380646-03-6
Molecular Formula:C₂₄H₂₁FN₂O₄S
Molecular Weight:452.506
Hs Code.:

Synonyms:N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide

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Technology Process of N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide

There total 4 articles about N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 4570-41-6
1,3-benzoxazol-2-amine

: 1380646-57-0
3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

: 1380646-03-6
N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 90532-02-8
1-bromo-2-methyl-4-methylsulfanylbenzene

: 1380646-03-6
N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / diethyl ether; tetrahydrofuran / 0.08 h / 120 °C / Inert atmosphere; Microwave reactor

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3.2: 3 h / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1380646-55-8
(2-methyl-4-methylsulfanylphenyl)-acetic acid tert-butyl ester

: 1380646-03-6
N-Benzooxazol-2-yl-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2.2: 3 h / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;