3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

Base Information

Chemical Name:3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid
CAS No.:1380646-57-0
Molecular Formula:C₁₇H₁₇FO₄S
Molecular Weight:336.384
Hs Code.:

Synonyms:3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

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Chemical Property of 3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

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Technology Process of 3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

There total 3 articles about 3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1380646-56-9
3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester

: 1380646-57-0
3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

Guidance literature:: 3-(4-fluorophenyl)-2-(2-methyl-4-methylsulfanyl-phenyl)-propionic acid tert-butyl ester; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 90532-02-8
1-bromo-2-methyl-4-methylsulfanylbenzene

: 1380646-57-0
3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / diethyl ether; tetrahydrofuran / 0.08 h / 120 °C / Inert atmosphere; Microwave reactor

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3.2: 3 h / 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1380646-55-8
(2-methyl-4-methylsulfanylphenyl)-acetic acid tert-butyl ester

: 1380646-57-0
3-(4-fluorophenyl)-2-(4-methanesulfonyl-2-methyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2.2: 3 h / 20 °C

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;