2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide

Base Information

• Chemical Name: 2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide
• CAS No.: 100695-82-7
• Molecular Formula: C₁₆H₁₅NO₃S
• Molecular Weight: 301.366
• Mol file: 100695-82-7.mol

Synonyms:2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide

Chemical Property of 2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide

There total 6 articles about 2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

o-iodo-methyl-benzoic acid (610-97-9) + N-methyl-2-sulfanylbenzamide (20054-45-9) → 2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide (100695-82-7)

Guidance literature:

With copper(I) oxide; In pyridine; for 2h; Heating;

DOI:10.1039/b008156f

Reference yield:

2-(methoxycarbonyl)phenyl 2-carboxyphenyl sulfide (67889-22-9) → 2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide (100695-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: diethyl ether / 2 h

With thionyl chloride; In diethyl ether;

DOI:10.1246/bcsj.58.1946

Reference yield:

2,2'-dithiodibenzoic acid dichloride (19602-82-5) → 2-(N-methylcarbamoyl)phenyl 2-(methoxycarbonyl)phenyl sulfide (100695-82-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 147 g / benzene; tetrahydrofuran / 0 - 20 °C

2: 40 percent / Zn; AcOH / 6 h / Heating

3: 70 percent / Cu₂O / pyridine / 2 h / Heating

With copper(I) oxide; acetic acid; zinc; In tetrahydrofuran; pyridine; benzene;

DOI:10.1039/b008156f

upstream raw materials:

2-(2-Chlorocarbonyl-phenylsulfanyl)-benzoic acid methyl ester

methylamine

o-iodo-methyl-benzoic acid

N-methyl-2-sulfanylbenzamide

Downstream raw materials:

2-(hydroxymethyl)-2'-<(methylamino)methyl>diphenyl sulfide