N-Benzyl-N,alpha-dimethylphenethylamine

Base Information

• Chemical Name: N-Benzyl-N,alpha-dimethylphenethylamine
• CAS No.: 101-47-3
• Deprecated CAS: 51287-28-6
• Molecular Formula: C17H21 N
• Molecular Weight: 239.36
• UNII: QZH832I91B
• DSSTox Substance ID: DTXSID50859308
• Nikkaji Number: J292.236C
• Wikidata: Q100325978
• Mol file: 101-47-3.mol

Synonyms:Benzfetamine;Benzphetamine;Didrex

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Chemical Property of N-Benzyl-N,alpha-dimethylphenethylamine

Chemical Property:

• Boiling Point: 334.3°Cat760mmHg
• Flash Point: 141.5°C
• PSA: 3.24000
• Density: 0.996g/cm³
• LogP: 3.74960
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 5
• Exact Mass: 239.167399674
• Heavy Atom Count: 18
• Complexity: 214

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)N(C)CC2=CC=CC=C2

Technology Process of N-Benzyl-N,alpha-dimethylphenethylamine

There total 5 articles about N-Benzyl-N,alpha-dimethylphenethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-propenylbenzene (873-66-5) + benzyl-methyl-amine (103-67-3) → benzphetamine (101-47-3)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, 0 deg C, 2) THF, 0 deg C, overnight;

DOI:10.1016/S0040-4039(98)00907-1

Reference yield:

→ benzphetamine (101-47-3)

Guidance literature:

Reference yield:

benzylamine (100-46-9) → benzphetamine (101-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; titanium isopropoxide / ethanol / 12 h / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: formic acid / 12 h / 90 °C

With titanium isopropoxide; formic acid; triethylamine; In ethanol;

DOI:10.1021/acs.joc.2c00046

upstream raw materials:

1-propenylbenzene

benzyl-methyl-amine

formaldehyd

1-phenyl-2-benzylaminopropane