2-(4-Fluorophenyl)-5-(piperidin-4-yl)-3-(4-pyridyl)-pyrrole

Base Information

Chemical Name:2-(4-Fluorophenyl)-5-(piperidin-4-yl)-3-(4-pyridyl)-pyrrole
CAS No.:188343-78-4
Molecular Formula:C₂₀H₂₀FN₃
Molecular Weight:321.397
Hs Code.:
ChEMBL ID:CHEMBL2333852
DSSTox Substance ID:DTXSID301173918

Synonyms:SCHEMBL5725550;CHEMBL2333852;VTRDFQVZALPXRU-UHFFFAOYSA-N;DTXSID301173918;2-(4-fluorophenyl)-5-(piperidin-4-yl)-3-(4-pyridyl)-pyrrole;188343-78-4;4-[2-(4-Fluorophenyl)-5-(4-piperidinyl)-1H-pyrrol-3-yl]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Fluorophenyl)-5-(piperidin-4-yl)-3-(4-pyridyl)-pyrrole

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:321.16412581
Heavy Atom Count:24
Complexity:384

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1C2=CC(=C(N2)C3=CC=C(C=C3)F)C4=CC=NC=C4

Technology Process of 2-(4-Fluorophenyl)-5-(piperidin-4-yl)-3-(4-pyridyl)-pyrrole

There total 6 articles about 2-(4-Fluorophenyl)-5-(piperidin-4-yl)-3-(4-pyridyl)-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-89-4
picoline

: 188343-78-4
2-(4-fluorophenyl)-5-(piperidin-4-yl)-3-(pyridin-4-yl)-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: NaH; DMSO / 0 °C

2.2: dimethylsulfoxide

3.1: ammonium acetate; acetic acid / 110 °C

4.1: H₂ / Pd/C

With ammonium acetate; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.04.060

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 188343-78-4
2-(4-fluorophenyl)-5-(piperidin-4-yl)-3-(pyridin-4-yl)-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: NaH; DMSO / 0 °C

2.2: dimethylsulfoxide

3.1: ammonium acetate; acetic acid / 110 °C

4.1: H₂ / Pd/C

With ammonium acetate; hydrogen; sodium hydride; acetic acid; dimethyl sulfoxide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.04.060