4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione

Base Information

Chemical Name:4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione
CAS No.:188345-15-5
Molecular Formula:C₂₈H₂₇FN₂O₄
Molecular Weight:474.532
Hs Code.:

Synonyms:4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione

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Chemical Property of 4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione

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Technology Process of 4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione

There total 10 articles about 4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 6576-05-2
1-(4-fluorophenyl)-2-(4-pyridyl)ethanone

: 85475-10-1
4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester

: 188345-15-5
4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione

Guidance literature:: 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; for 0.583333h; Inert atmosphere;

4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester; In tetrahydrofuran; dimethyl sulfoxide; for 2h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.01.010

Reference yield:

: 4-(2-iodoacetyl)-1-(benzyloxycarbonyl)piperidine

: 188345-15-5
4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 6576-05-2
1-(4-fluorophenyl)-2-(4-pyridyl)ethanone

: 816464-47-8
benzyl 4-(2-bromoacetyl)piperidine-1-carboxylate

: 188345-15-5
4-(1-benzyloxycarbonylpiperidin-4-yl)-2-(pyridin-4-yl)-1-(4-fluoro-phenyl)butane-1,4-dione

Guidance literature:: 1-(4-fluorophenyl)-2-(4-pyridyl)ethanone; With lithium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

benzyl 4-(2-bromoacetyl)piperidine-1-carboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.75h;