2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate

Base Information

Chemical Name:2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate
CAS No.:339544-51-3
Molecular Formula:C₂₃H₃₃NO₃SSi
Molecular Weight:431.671
Hs Code.:

Synonyms:2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate

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Chemical Property of 2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate

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Technology Process of 2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate

There total 6 articles about 2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103-71-9
phenyl isocyanate

: 339354-94-8
2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

: 339544-51-3
2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate

Guidance literature:: With dmap; In tetrahydrofuran; at 50 ℃; for 2h;
DOI:10.1021/jm020868v

Reference yield:

: 52130-17-3
3-amino-2-methylbenzoic acid

: 339544-51-3
2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: HCl; NaNO₂ / H₂O / 0 °C

1.2: Na₂CO₃ / methanol; H₂O / 0.75 h / 60 - 70 °C / pH 5 - 6

2.1: 5 g / BH₃*THF / 1 h / 0 °C

3.1: 95 percent / imidazole / dimethylformamide / 0.75 h / 20 °C

4.1: 86 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

5.1: DMAP / tetrahydrofuran / 2 h / 50 °C

With 1H-imidazole; hydrogenchloride; dmap; lithium aluminium tetrahydride; borane-THF; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020868v

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 339544-51-3
2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}ethyl phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole / dimethylformamide / 0.75 h / 20 °C

2: 86 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

3: DMAP / tetrahydrofuran / 2 h / 50 °C

With 1H-imidazole; dmap; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020868v