2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

Base Information

Chemical Name:2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol
CAS No.:339354-94-8
Molecular Formula:C₁₆H₂₈O₂SSi
Molecular Weight:312.549
Hs Code.:

Synonyms:2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

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Chemical Property of 2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

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Technology Process of 2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

There total 5 articles about 2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 339544-50-2
methyl 2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}acetate

: 339354-94-8
2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/jm020868v

Reference yield:

: 52130-17-3
3-amino-2-methylbenzoic acid

: 339354-94-8
2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: HCl; NaNO₂ / H₂O / 0 °C

1.2: Na₂CO₃ / methanol; H₂O / 0.75 h / 60 - 70 °C / pH 5 - 6

2.1: 5 g / BH₃*THF / 1 h / 0 °C

3.1: 95 percent / imidazole / dimethylformamide / 0.75 h / 20 °C

4.1: 86 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; borane-THF; sodium nitrite; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1021/jm020868v

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 339354-94-8
2-{[3-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-methylphenyl]sulfanyl}-1-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / imidazole / dimethylformamide / 0.75 h / 20 °C

2: 86 percent / LAH / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; lithium aluminium tetrahydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm020868v