(2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester

Base Information

• Chemical Name: (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester
• CAS No.: 189562-46-7
• Molecular Formula: C₂₅H₂₇NO₃
• Molecular Weight: 389.494
• Mol file: 189562-46-7.mol

Synonyms:(2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester

Chemical Property of (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester

There total 3 articles about (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(3S)-3-N,N-dibenzylamino-2-oxo-4-phenylbutyric acid methyl ester (148692-42-6) → (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester (189562-46-7)

Guidance literature:

With sodium borohydrid; In methanol;

Reference yield: 74.0%

1 N-hydrochloric acid + (3S)-3-N,N-dibenzylamino-2-oxo-4-phenylbutyric acid methyl ester (148692-42-6) → (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester (189562-46-7)

Guidance literature:

With sodium borohydrid; In methanol;

Reference yield:

methanol (67-56-1) + (2S, 3S)-3-N,N-dibenzylamino-2-acetyloxy-4-phenylbutyronitrile (313468-89-2) → (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester (189562-46-7) + methyl (2S,3S)-3-dibenzylamino-2-hydroxy-4-phenylbutyrate

Guidance literature:

methanol; (2S, 3S)-3-N,N-dibenzylamino-2-acetyloxy-4-phenylbutyronitrile; With hydrogenchloride; at 5 - 25 ℃; for 15h;

In water; at 50 ℃; for 2h;

upstream raw materials:

methanol

(2S, 3S)-3-N,N-dibenzylamino-2-acetyloxy-4-phenylbutyronitrile

(3S)-3-N,N-dibenzylamino-2-oxo-4-phenylbutyric acid methyl ester

Downstream raw materials:

(2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanoic acid