313468-89-2

Upstream product

• 631-57-2 Acetyl cyanide 
• 123054-12-6 (2S)-N,N-dibenzylphenylalaninal 
• 143-33-9 sodium cyanide 
• 108-24-7 acetic anhydride 

Downstream Products

• 153291-28-2 (2S,3S)-3-(N,N-dibenzylamino)-2-hydroxy-4-phenylbutyric acid 
• 195510-33-9 (2R,3S)-3-(dibenzylamino)-2-hydroxy-4-phenylbutanoic acid 
• 189562-46-7 (2R,3S)-3-N,N-dibenzylamino-2-hydroxy-4-phenylbutyric acid methyl ester 

Relevant academic research and scientific papers

Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives

The present invention relates to a process for reacting α-aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to synthesize 3-amino-2-hydroxybutyronitrile derivatives in high yields and high erythro selectivity. When optically active α-aminoaldehyde derivatives are used, racemization hardly occurs during the reaction, and the desired products are obtained in high optical purity.