2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

Base Information

Chemical Name:2-chloro-4-cyano-3-methoxybenzoic acid methyl ester
CAS No.:1207343-94-9
Molecular Formula:C₁₀H₈ClNO₃
Molecular Weight:225.631
Hs Code.:

Synonyms:2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

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Chemical Property of 2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

Chemical Property:

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Technology Process of 2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

There total 6 articles about 2-chloro-4-cyano-3-methoxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

: 557-21-1
zinc(II) cyanide

: 1207344-03-3
4-bromo-2-chloro-3-methoxybenzoic acid methyl ester

: 1207343-94-9
2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

Guidance literature:: (diphenylphosphin)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In ISOPROPYLAMIDE; for 2h; Reflux;

Reference yield:

: 1207343-84-7
2-chloro-3-dimethoxymethyl phenol

: 1207343-94-9
2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / chloroform / 20 °C / Cooling with ice

2.1: aminosulfonic acid / water; tetrahydrofuran / 0.33 h / 20 °C

2.2: 3.5 h / 20 °C

3.1: sulfuric acid / 7.5 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (diphenylphosphin)ferrocene / ISOPROPYLAMIDE / 2 h / Reflux

With sulfuric acid; aminosulfonic acid; bromine; potassium carbonate; (diphenylphosphin)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; chloroform; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 56962-10-8
2-chloro-3-hydroxybenzaldehyde

: 1207343-94-9
2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / methanol

2.1: bromine / chloroform / 20 °C / Cooling with ice

3.1: aminosulfonic acid / water; tetrahydrofuran / 0.33 h / 20 °C

3.2: 3.5 h / 20 °C

4.1: sulfuric acid / 7.5 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (diphenylphosphin)ferrocene / ISOPROPYLAMIDE / 2 h / Reflux

With sulfuric acid; aminosulfonic acid; bromine; potassium carbonate; hydrogenchloride; (diphenylphosphin)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; chloroform; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;