2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester

Base Information

Chemical Name:2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester
CAS No.:1207343-95-0
Molecular Formula:C₉H₆ClNO₃
Molecular Weight:211.605
Hs Code.:

Synonyms:2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester

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Chemical Property of 2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester

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Technology Process of 2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester

There total 6 articles about 2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.8%

: 1207343-94-9
2-chloro-4-cyano-3-methoxybenzoic acid methyl ester

: 1207343-95-0
2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester

Guidance literature:: With boron tribromide; In dichloromethane; at -10 - 20 ℃;

Reference yield:

: 1207343-84-7
2-chloro-3-dimethoxymethyl phenol

: 1207343-95-0
2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / chloroform / 20 °C / Cooling with ice

2.1: aminosulfonic acid / water; tetrahydrofuran / 0.33 h / 20 °C

2.2: 3.5 h / 20 °C

3.1: sulfuric acid / 7.5 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (diphenylphosphin)ferrocene / ISOPROPYLAMIDE / 2 h / Reflux

6.1: boron tribromide / dichloromethane / -10 - 20 °C

With sulfuric acid; aminosulfonic acid; bromine; boron tribromide; potassium carbonate; (diphenylphosphin)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; chloroform; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;

Reference yield:

: 56962-10-8
2-chloro-3-hydroxybenzaldehyde

: 1207343-95-0
2-chloro-4-cyano-3-hydroxybenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / methanol

2.1: bromine / chloroform / 20 °C / Cooling with ice

3.1: aminosulfonic acid / water; tetrahydrofuran / 0.33 h / 20 °C

3.2: 3.5 h / 20 °C

4.1: sulfuric acid / 7.5 h / Reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; (diphenylphosphin)ferrocene / ISOPROPYLAMIDE / 2 h / Reflux

7.1: boron tribromide / dichloromethane / -10 - 20 °C

With sulfuric acid; aminosulfonic acid; bromine; boron tribromide; potassium carbonate; hydrogenchloride; (diphenylphosphin)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; chloroform; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide;