ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate

Base Information

Chemical Name:ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate
CAS No.:1352837-10-5
Molecular Formula:C₃₀H₂₆BrN₃O₄
Molecular Weight:572.458
Hs Code.:

Synonyms:ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate

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Chemical Property of ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate

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Technology Process of ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate

There total 8 articles about ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1352837-08-1
ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

: 1352837-10-5
ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: palladium 10% on activated carbon; In xylene; at 120 ℃;

Reference yield:

: 69022-35-1
2-methyl-3-amino-benzonitrile

: 1352837-10-5
ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

2.2: 0.5 h / 20 °C / Cooling with ice

3.1: ammonium acetate; acetic acid / 95 °C

4.1: 140 °C

5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / Inert atmosphere

6.1: hydrogenchloride / toluene; 1,4-dioxane / 20 °C / Inert atmosphere

7.1: palladium 10% on activated carbon / xylene / 120 °C

With hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; xylene;

Reference yield:

: 71516-35-3
2-methyl-3-nitrobenzonitrile

: 1352837-10-5
ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-9H-pyrido[3,4-b]indole-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 0 - 20 °C

2.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C

3.2: 0.5 h / 20 °C / Cooling with ice

4.1: ammonium acetate; acetic acid / 95 °C

5.1: 140 °C

6.1: zinc; ammonium chloride / tetrahydrofuran; methanol / Inert atmosphere

7.1: hydrogenchloride / toluene; 1,4-dioxane / 20 °C / Inert atmosphere

8.1: palladium 10% on activated carbon / xylene / 120 °C

With hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; xylene;