Technology Process of ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
There total 7 articles about ethyl 4-(3-(((benzyloxy)carbonyl)amino)-2-methylphenyl)-7-bromo-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
glyoxylic acid ethyl ester; benzyl (3-(2-amino-1-(6-bromo-1H-indol-3-yl)propyl)-2-methylphenyl)carbamate;
With
hydrogenchloride;
In
1,4-dioxane; toluene;
at 20 ℃;
Inert atmosphere;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C
2.2: 0.5 h / 20 °C / Cooling with ice
3.1: ammonium acetate; acetic acid / 95 °C
4.1: 140 °C
5.1: zinc; ammonium chloride / tetrahydrofuran; methanol / Inert atmosphere
6.1: hydrogenchloride / toluene; 1,4-dioxane / 20 °C / Inert atmosphere
With
hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: zinc; ammonium chloride / tetrahydrofuran; methanol / 2 h / 0 - 20 °C
2.1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 5.75 h / -78 - 20 °C
3.2: 0.5 h / 20 °C / Cooling with ice
4.1: ammonium acetate; acetic acid / 95 °C
5.1: 140 °C
6.1: zinc; ammonium chloride / tetrahydrofuran; methanol / Inert atmosphere
7.1: hydrogenchloride / toluene; 1,4-dioxane / 20 °C / Inert atmosphere
With
hydrogenchloride; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; ammonium chloride; acetic acid; zinc;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;
