C₃₁H₄₃BN₂O₈

Base Information

• Chemical Name: C₃₁H₄₃BN₂O₈
• CAS No.: 1305317-50-3
• Molecular Formula: C₃₁H₄₃BN₂O₈
• Molecular Weight: 582.502
• Mol file: 1305317-50-3.mol

Synonyms:C₃₁H₄₃BN₂O₈

Chemical Property of C₃₁H₄₃BN₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₃₁H₄₃BN₂O₈

There total 5 articles about C₃₁H₄₃BN₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-methyl 2-amino-3-(4-methoxy-3-(4,4,5 ,5-tetramethyl-1,3 ,2-dioxaborolan-2-yl)phenyl)propanoate (1004524-42-8) + C25H31IN2O6 (1305317-49-0) → C31H43BN2O8 (1305317-50-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 20 - 80 ℃; for 2.5h; Inert atmosphere;

Reference yield:

C25H31IN2O6 (1305317-49-0) + bis(pinacol)diborane (73183-34-3) → C25H33BN2O8 + C31H43BN2O8 (1305317-50-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/np200163g

Reference yield:

(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid (1086703-05-0) → C25H33BN2O8 + C31H43BN2O8 (1305317-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

2: potassium carbonate / acetone / Reflux

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / dimethyl sulfoxide / 2.5 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; 3: Miyaura boration;

DOI:10.1021/np200163g

upstream raw materials:

(S)-2-(tert-butoxycarbonyl(methyl)amino)-2-(4-hydroxy-3-iodophenyl)acetic acid

C₂₅H₃₁IN₂O₆

bis(pinacol)diborane

L-alanine benzyl ester hydrochloride

Downstream raw materials:

C₃₅H₄₈BIN₄O₁₂

C₂₄H₃₇BN₂O₈