4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester

Base Information

• Chemical Name: 4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester
• CAS No.: 1337908-27-6
• Molecular Formula: C₁₈H₁₈O₄
• Molecular Weight: 298.339
• Mol file: 1337908-27-6.mol

Synonyms:4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester

Chemical Property of 4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester

There total 4 articles about 4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-formylfurane-2-boronic acid (27329-70-0) + 4-(4-bromophenyl)butanoic acid (35656-89-4) + allyl alcohol (107-18-6) → 4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester (1337908-27-6)

Guidance literature:

5-formylfurane-2-boronic acid; 4-(4-bromophenyl)butanoic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; at 95 ℃; for 24h;

allyl alcohol; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.202109349

Reference yield:

4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid (1337908-31-2) + allyl alcohol (107-18-6) → 4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester (1337908-27-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 48h;

DOI:10.1039/c1cc14045k

Reference yield:

4-(4-bromophenyl)butanoic acid (35656-89-4) → 4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester (1337908-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 0 - 20 °C

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,2-dimethoxyethane; dichloromethane; water;

DOI:10.1039/c1cc14045k

upstream raw materials:

4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid

allyl alcohol

5-formylfurane-2-boronic acid

4-(4-bromophenyl)butanoic acid

Downstream raw materials:

C₁₉H₁₉NO₃

2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester