2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester

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Chemical Name:2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester
CAS No.:1337908-28-7
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:

Synonyms:2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester

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Chemical Property of 2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester

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Technology Process of 2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester

There total 5 articles about 2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 6367-36-8
tert-butyl 2-azidoacetate

: 1337908-31-2
4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid

: 1337908-28-7
2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; tert-butyl alcohol; at -18 ℃; for 5.5h; Inert atmosphere;
DOI:10.1039/c1cc14045k

Reference yield:

: 6367-36-8
tert-butyl 2-azidoacetate

: 1337908-27-6
4-[4-(5-formyl-furan-2-yl)-phenyl]-butyric acid allyl ester

: 1337908-28-7
2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; toluene; tert-butyl alcohol; at -18 - 120 ℃; for 1h;
DOI:10.1002/anie.202109349

Reference yield:

: 27329-70-0
5-formylfurane-2-boronic acid

: 1337908-28-7
2-[4-(3-allyloxycarbonyl-propyl)-phenyl]-4H-furo[3,2-b]pyrrole-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 5.5 h / -18 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; 1,2-dimethoxyethane; water; tert-butyl alcohol;
DOI:10.1039/c1cc14045k