methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

Base Information

• Chemical Name: methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate
• CAS No.: 172846-56-9
• Molecular Formula: C₂₇H₃₄N₂O₆
• Molecular Weight: 482.577
• Mol file: 172846-56-9.mol

Synonyms:methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

Chemical Property of methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate

There total 6 articles about methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → methyl N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate (172846-56-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1002/chem.202104178

Reference yield: 95.0%

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) + methyl iodide (74-88-4) → methyl N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate (172846-56-9)

Guidance literature:

With Cs₂CO₃; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

DOI:10.1039/d1ob02461b

Reference yield: 88.0%

Nα-(benzyloxycarbonyl)-Nε-(tert-butoxycarbonyl)-L-lysine methyl ester (2389-49-3) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → methyl N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(tert-butoxycarbonyl)-L-lysinate (172846-56-9)

Guidance literature:

With [2,2]bipyridinyl; hydrogen; palladium on activated charcoal; In methanol; for 7h;

DOI:10.1016/S0040-4039(00)01811-6

upstream raw materials:

di-tert-butyl dicarbonate

N^α-(benzyloxycarbonyl)-N^ε-(tert-butoxycarbonyl)-L-lysine methyl ester

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

diazomethane

Downstream raw materials:

(S)-methyl 2-amino-6-(tert-butoxycarbonylamino)hexanoate

L-lysine methyl ester

Fmoc-Lys-OH

2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid