Technology Process of 1-(1-(2-(2-hydroxy-4-(1-(methylsulfonyl)piperidin-4-yloxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one
There total 8 articles about 1-(1-(2-(2-hydroxy-4-(1-(methylsulfonyl)piperidin-4-yloxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 14h;
chemoselective reaction;
DOI:10.1016/j.bmc.2012.02.019
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydroxide / methanol; water / 24 h / Reflux
2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
3: hydrogenchloride / diethyl ether; dichloromethane / 12 h / 20 °C / Inert atmosphere
4: triethylamine / dichloromethane / 14 h / 20 °C
With
hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.02.019
- Guidance literature:
-
Multi-step reaction with 7 steps
1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 20 h / 0 - 20 °C
2: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere
3: sulfur / 5 h / 135 - 140 °C
4: sodium hydroxide / methanol; water / 24 h / Reflux
5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere
6: hydrogenchloride / diethyl ether; dichloromethane / 12 h / 20 °C / Inert atmosphere
7: triethylamine / dichloromethane / 14 h / 20 °C
With
hydrogenchloride; benzotriazol-1-ol; caesium carbonate; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene;
3: Wilgerodt-Kindler reaction;
DOI:10.1016/j.bmc.2012.02.019
