rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

Base Information

Chemical Name:rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide
CAS No.:1290097-24-3
Molecular Formula:C₂₇H₃₁Cl₂F₂N₃O₃
Molecular Weight:554.464
Hs Code.:

rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

Synonyms:rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

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Chemical Property of rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

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Technology Process of rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

There total 7 articles about rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1008526-48-4
(S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethan-1-amine

: rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl chloride

: 1290097-24-3
rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

Guidance literature:: (S)-2-(2,2-dimethyl-1,3-dioxolan-4-yl)ethan-1-amine; rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carbonyl chloride; In tetrahydrofuran; at 20 ℃; for 0.5h;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 75279-53-7
2-(4-chloro-2-fluoro-phenyl)acetonitrile

: 1290097-24-3
rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol / 5 h / 45 °C

2.1: acetic acid / N,N,N,N,N,N-hexamethylphosphoric triamide; water / 18 h / 20 °C

3.1: sodium hydrogencarbonate / dichloromethane; toluene / 0 - 20 °C

4.1: tetrahydrofuran / 0.5 h / 20 °C

4.2: 1 h / 20 °C

With sodium methylate; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; toluene;

Reference yield:

: 1219086-87-9
(Z)-3-(3-chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)prop-2-enenitrile

: 1290097-24-3
rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / N,N,N,N,N,N-hexamethylphosphoric triamide; water / 18 h / 20 °C

2.1: sodium hydrogencarbonate / dichloromethane; toluene / 0 - 20 °C

3.1: tetrahydrofuran / 0.5 h / 20 °C

3.2: 1 h / 20 °C

With sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; toluene;