1219086-87-9

Basic information

• Product Name: (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile
• Synonyms: (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile
• CAS NO: 1219086-87-9
• Molecular Weight: 310.13
• Mol File: 1219086-87-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile(1219086-87-9)
• EPA Substance Registry System: (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile(1219086-87-9)

Safety Data

• Hazardous Substances Data: 1219086-87-9(Hazardous Substances Data)

Usage

General Description

The chemical (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile is a nitrile compound with two aromatic rings and a nitrile functional group. It is a derivative of 2-propenenitrile with substituted chloro and fluoro groups on the phenyl rings. The compound is also known as (Z)-3-(3,4-dichloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)acrylonitrile. The specific arrangement of the substituents on the phenyl rings gives it the (Z) configuration. (Z)-3-(3-Chloro-2-fluorophenyl)-2-(4-chloro-2-fluorophenyl)-2-propenenitrile may have applications in chemical synthesis, pharmaceuticals, and materials science due to its unique structural features and potential reactivity.

Upstream product

• 75279-53-7 2-(4-chloro-2-fluoro-phenyl)acetonitrile 
• 85070-48-0 2-fluoro-3-chlorobenzaldehyde 

Downstream Products

• 1290097-24-3 rac-(2S,3R,4S)-4-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-2-(2,2-dimethylpropyl)pyrrolidine-1-carboxylic acid ((S)-3,4-dihydroxybutyl)amide 

Relevant articles and documents

Practical Synthesis of MDM2 Antagonist RG7388. Part 2: Development of the Cu(I) Catalyzed [3 + 2] Asymmetric Cycloaddition Process for the Manufacture of Idasanutlin

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MDM2 DEGRADERS AND USES THEREOF

The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog ("MDM2") protein via ubiquitination and/or degradation by compounds according to the present invention.

MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of Kirsten rat sarcoma protein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation, accumulation, and/or overactivation of the target protein are treated or prevented with compounds and compositions of the present disclosure.