(S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

Base Information

Chemical Name:(S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one
CAS No.:1144528-36-8
Molecular Formula:C₂₁H₂₅BO₃
Molecular Weight:336.239
Hs Code.:

Synonyms:(S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

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Technology Process of (S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

There total 7 articles about (S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 94-41-7
benzalacetophenone

: 73183-34-3
bis(pinacol)diborane

: 1144528-36-8
(S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

Guidance literature:: bis(pinacol)diborane; With copper(I) oxide; C₂₅H₃₀N₃O⁽¹⁺⁾*Cl^(1-); caesium carbonate; In toluene; at 0 - 20 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

benzalacetophenone; In methanol; toluene; at 0 ℃; for 0.333333h; enantioselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1039/c5ob01609f

Reference yield: 43.0%

: 4360-47-8
cinnamonitrile

: 94-41-7
benzalacetophenone

: 73183-34-3
bis(pinacol)diborane

: 1006696-26-9
(S)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

: 1144528-36-8
(S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

Guidance literature:: With methanol; (R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocene]ethyldicyclohexylphosphine; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; at 25 ℃; for 24h; enantioselective reaction;
DOI:10.1002/cctc.202101278

Reference yield:

: 614-47-1
1,3-diphenyl-propen-3-one

: 73183-34-3
bis(pinacol)diborane

: 1144528-36-8
(S)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

: 1333225-65-2
(R)-1,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propan-1-one

Guidance literature:: With methanol; BF₄^(1-)*C₄₂H₄₅N₂⁽¹⁺⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 22 ℃; for 18h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja302929d