5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine

Base Information

• Chemical Name: 5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine
• CAS No.: 1352565-07-1
• Molecular Formula: C₃₄H₃₂FN₃
• Molecular Weight: 501.647

Synonyms:5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine

Chemical Property of 5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine

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Technology Process of 5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine

There total 4 articles about 5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

N-(4-fluorobenzyl)-3,5-bis(4-methylbenzylidene)-4-piperidone (1350909-75-9) + phenylhydrazine (100-63-0) → 5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine (1352565-07-1)

Guidance literature:

With sodium ethanolate; In ethanol; Reflux;

DOI:10.1007/s11426-013-4840-x

Reference yield:

C15H20FNO4 (1225789-29-6) → 5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine (1352565-07-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium methylate / methanol; toluene / Reflux

2.1: hydrogenchloride; water / Reflux

2.2: 20 °C

3.1: sodium hydroxide / ethanol / 20 °C

4.1: sodium ethanolate / ethanol / Reflux

With hydrogenchloride; water; sodium methylate; sodium ethanolate; sodium hydroxide; In methanol; ethanol; toluene;

DOI:10.1007/s11426-013-4840-x

Reference yield:

1-(4-Fluorobenzyl)-4-piperidone (134348-51-9) → 5-(4-fluorobenzyl)-7-(4-methylbenzylidene)-3,3a,4,5,6,7-hexahydro-3-(4-methylphenyl)-2-phenyl-2H-pyrazolo[4,3-c]pyridine (1352565-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 20 °C

2: sodium ethanolate / ethanol / Reflux

With sodium ethanolate; sodium hydroxide; In ethanol;

DOI:10.1007/s11426-013-4840-x

upstream raw materials:

C₁₅H₂₀FNO₄

1-(4-Fluorobenzyl)-4-piperidone

para-fluorobenzylamine

N-(4-fluorobenzyl)-3,5-bis(4-methylbenzylidene)-4-piperidone

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