(R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

Base Information

Chemical Name:(R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol
CAS No.:1142232-50-5
Molecular Formula:C₂₄H₃₆FNO₃Si
Molecular Weight:433.639
Hs Code.:

Synonyms:(R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

Suppliers and Price of (R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of (R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

There total 8 articles about (R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1142232-49-2
(R)-1-(2-(5-fluoro-2-methoxypyridin-4-yl)-5-(hydroxymethyl)phenyl)-2,2-dimethylpropan-1-ol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1142232-50-5
(R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 23 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ml4005123

Reference yield:

: 1142232-40-3
4-(5-fluoro-2-(methyloxy)-4-pyridinyl)-3-((methyloxy)carbonyl)benzoic acid

: 1142232-50-5
(R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

2: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

4: Chiracel-OD / hexane / Inert atmosphere; Resolution of racemate

5: triethylamine; dmap / dichloromethane / 24 h / 23 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; borane-THF; triethylamine; In tetrahydrofuran; hexane; dichloromethane; pentane;
DOI:10.1021/ml4005123

Reference yield:

: 1142232-39-0
dimethyl 4-(5-fluoro-2-(methyloxy)-4-pyridinyl)-1,3-benzenedicarboxylate

: 1142232-50-5
(R)-1-(5-(((tert-butyldimethylsilyl)oxy)methyl)-2-(5-fluoro-2-methoxypyridin-4-yl)phenyl)-2,2-dimethylpropan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: potassium hydroxide / tetrahydrofuran; methanol / 17 h / 0 - 20 °C / Inert atmosphere

2: borane-THF / tetrahydrofuran / 46 h / 23 °C / Inert atmosphere

3: tetrahydrofuran; pentane / 1 h / -78 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

5: Chiracel-OD / hexane / Inert atmosphere; Resolution of racemate

6: triethylamine; dmap / dichloromethane / 24 h / 23 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; borane-THF; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; pentane;
DOI:10.1021/ml4005123