tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate
CAS No.:1280210-86-7
Molecular Formula:C₁₆H₁₉F₂IN₂O₃
Molecular Weight:452.24
Hs Code.:

Synonyms:tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate

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Chemical Property of tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate

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Technology Process of tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate

There total 3 articles about tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280210-85-6
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-6-oxopiperidin-3-yl]carbamate

: 1280210-86-7
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate

Guidance literature:: tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-6-oxopiperidin-3-yl]carbamate; With trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; In dichloromethane; at 0 ℃; for 2h;

With iodine; In methanol; for 3h;

With sodium thiosulfate; In dichloromethane; water; for 0.166667h;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1280210-86-7
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate / ethanol / 16 h / Reflux

2.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

2.2: 15 h / 0 - 20 °C

3.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

3.2: 3 h

3.3: 0.17 h

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; ammonium acetate; nickel (II) chloride hexahydrate; In methanol; ethanol; dichloromethane;

Reference yield:

: 1280210-82-3
(5S,6R)-6-(2,5-difluorophenyl)-5-nitropiperidin-2-one

: 1280210-86-7
tert-butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-iodo-6-oxopiperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / nickel (II) chloride hexahydrate / methanol / 1 h / 0 °C

1.2: 15 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; trimethylsilyl iodide / dichloromethane / 2 h / 0 °C

2.2: 3 h

2.3: 0.17 h

With sodium tetrahydroborate; trimethylsilyl iodide; N,N,N,N,-tetramethylethylenediamine; nickel (II) chloride hexahydrate; In methanol; dichloromethane;